A major scientific breakthrough has given new hope to people affected by Alzheimer’s disease. Researchers in Spain and China have successfully reversed Alzheimer’s symptoms in mice by helping the brain’s protective barrier work properly again.

The treatment uses nanoparticles to “remind” the blood-brain barrier (a protective layer around the brain) how to clear harmful substances. In Alzheimer’s, this process breaks down, causing the build-up of amyloid beta plaques that stop brain cells from communicating.

Within just an hour of the injection, researchers observed a 50–60% reduction in amyloid beta levels in the brain. Mice that received the treatment showed long-term improvements in memory and behaviour.

While this is still early research and human trials are yet to begin, the potential impact is enormous. Alzheimer’s is currently the leading cause of death in the UK, affecting nearly a million people. If this approach moves toward clinical trials and future treatment, it could have significant implications for dementia care and support.

We’ll be updating our learning materials and resources as soon as new evidence and best practice guidance become available.